Phenotypic analysis of human immunodeficiency virus type 1 Rev trimerization-interface mutants in human cells
نویسندگان
چکیده
منابع مشابه
Phenotypic analysis of human immunodeficiency virus type 1 Rev trimerization-interface mutants in human cells.
Nuclear export of unspliced and incompletely spliced human immunodeficiency virus type 1 mRNA is mediated by the viral Rev protein. Rev binds to a structured RNA motif known as the Rev-response element (RRE), which is present in all Rev-dependent transcripts, and thereby promotes entry of the ribonucleoprotein complex into the nuclear-export pathway. Recent evidence indicates that a dimerizatio...
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The human immunodeficiency virus type 1 (HIV-1) Rev and human T-cell leukemia virus type 1 (HTLV-1) Rex proteins are essential for the expression of viral structural proteins and productive infection. Both contain a nuclear export signal (NES) in their C-terminal domain and a nuclear localization signal (NLS) in their N-terminal domain. The NES and NLS are necessary for shuttling between nucleu...
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Visna virus encodes a posttranscriptional regulatory protein that is functionally analogous to the Rev trans activator of human immunodeficiency virus type 1. Here, we demonstrate that the known functional organization of the human immunodeficiency virus type 1 Rev trans activator is shared by the distantly related visna virus Rev protein. In particular, both Rev proteins contain an N-terminal ...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2005
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.80572-0